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Sulfated polysaccharide fraction from Gracilaria intermedia (PLS)

Target: PLS
Molecular classification: Polysaccharide, Sulfated galactan, Agarocolloid

Overview

A water-soluble sulfated polysaccharide fraction extracted from the red alga Gracilaria intermedia. This polymeric material is rich in agaran-type structures and exhibits significant antioxidant activity through mechanisms such as free radical scavenging and metal ion chelation. The extract has been shown to act as a non-synthetic antioxidant with potential applications in food preservation and pharmaceutical formulations. Its rheological properties also make it suitable as a thickening agent. The main biological function is cellular protection against oxidative damage by neutralizing reactive oxygen species.[1][2][3]

Other names: Gracilaria intermedia polysaccharidesred seaweed sulfated galactansagaransmarine algal sulfated polysaccharides

Mechanism of action

Free radical scavenging (e.g., DPPH radical inhibition); Metal ion chelation[1][2]

Biological functions

Antioxidant activity (free radical scavenging)Cellular protection against oxidative stressViscosity modification (thickening agent)

Disease associations

Oxidative stress-related diseases (e.g., cardiovascular disease)Inflammation[1][2][3]

Safety considerations

Limited clinical data on safety and toxicity in humans; generally considered safe as a food additive or pharmaceutical excipient based on organoleptic properties and preliminary studies[1]

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