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Target intelligence / Profile preview
Sulfonylurea Receptor 1–Transient Receptor Potential Melastatin 4 Channel (SUR1-TRPM4)
- Target
- SUR1-TRPM4
- Molecular classification
- Ion channel, ATP-binding cassette (ABC) protein, Transient receptor potential (TRP) channel, Heteromeric ion channel complex
01
Overview
The Sulfonylurea Receptor 1–Transient Receptor Potential Melastatin 4 Channel (SUR1–TRPM4) is an inducible nonselective cation channel implicated primarily in pathological responses following central nervous system injury. Its unique molecular composition confers both biophysical properties from TRPM4 and drug sensitivity from SUR1—making it an important target for therapeutic intervention aimed at limiting secondary neuronal damage after acute insults.
- Other names
- SUR1-NC(Ca-ATP)SUR1-NCCa-ATP channel
02
Mechanism of action
Inhibition of SUR1-TRPM4 channel activity
03
Biological functions
Ion transportRegulation of membrane potentialCalcium-activated cation channel activityCell depolarization
04
Disease associations
Ischemic strokeTraumatic brain injuryCerebral edemaNeuroinflammationNecrotic cell deathCentral nervous system injury
05
Safety considerations
Potential for hypoglycemia (if systemic effects of sulfonylureas are significant)Off-target effects of sulfonylureas
06
Interacting drugs
Glibenclamide (Glyburide)
1 more in the full profile.
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