Sulfotransferase family 1A member 3 (SULT1A3)

Sulfotransferase family 1A member 3 (SULT1A3) is a cytosolic enzyme that catalyzes the sulfate conjugation of phenolic monoamines using PAPS as the sulfonate donor, primarily targeting neurotransmitters like dopamine, norepinephrine, serotonin, and related catechol or phenolic compounds. This enzyme plays an essential role in the detoxification and presystemic elimination of dietary and endogenous catecholamines, both in the gastrointestinal tract and the brain, protecting against catecholamine-induced neurotoxicity. SULT1A3 is highly expressed in primates’ intestine, brain, platelets, lung, and kidney. Since its expression and catalytic activity vary among individuals and tissue types, it has implications for drug metabolism, interindividual variability in pharmacological responses, and potential links to neurological and metabolic disorders.

Other names

Sulfotransferase 1A3STMST1A3TL-PSTAryl sulfotransferase 1A3/1A4Catecholamine-sulfating phenol sulfotransferaseHAST3M-PSTMonoamine-sulfating phenol sulfotransferasePlacental estrogen sulfotransferaseSulfotransferase 1A3/1A4Sulfotransferase, monoamine-preferringThermolabile phenol sulfotransferaseHASTST1A3/ST1A4ST1A4ST1A5aryl sulfotransferase 1A3/1A4dopamine-specific sulfotransferasephenol sulfotransferase 1A5sulfokinasecytosolic phenol-preferring sulfotransferase, M-form

Drugs and endogenous substances are metabolized by sulfate conjugation using PAPS (3'-phospho-5'-adenylyl sulfate) as the sulfonate donor, thereby increasing water solubility and facilitating excretion Inactivation and detoxification of neurotransmitters by sulfation (dopamine sulfate formation)