Sulfotransferase family 1A member 4 (SULT1A4)

Sulfotransferase family 1A member 4 (SULT1A4) is a cytosolic enzyme that catalyzes the transfer of a sulfo group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to phenolic monoamines (e.g., dopamine, epinephrine, norepinephrine, serotonin), phenolic and catechol drugs, as well as some thyroid hormones[1][5][7]. It plays a significant role in the metabolism and inactivation or activation of catecholamine neurotransmitters and xenobiotic compounds. SULT1A4 shares an identical protein sequence with SULT1A3, and their activities are critical for regulating local tissue concentrations of monoamines and in bioactivation or detoxification of exogenous chemicals. Aberrant expression or altered activity of SULT1A enzymes has been implicated in susceptibility to chemical-induced toxicity and certain malignancies, due to their role in the bioactivation of some procarcinogens into DNA-reactive metabolites[2].

Other names

Sulfotransferase 1A4SULT1A4ST1A4Aryl sulfotransferase 1A3/1A4Sulfotransferase 1A3/1A4HAST3M-PSTST1A3ST1A3/ST1A4STMTL-PSTSLX1B-SULT1A4Sulfotransferase 1A3Catecholamine-sulfating phenol sulfotransferaseMonoamine-sulfating phenol sulfotransferasePlacental estrogen sulfotransferaseSulfokinaseSulfotransferase, monoamine-preferringThermolabile phenol sulfotransferase

Sulfate conjugation of xenobiotics, hormones, and neurotransmitters, facilitating their elimination or changing their biological activity. Some drugs require SULT1A-mediated sulfation for bioactivation, detoxification, or conversion to reactive metabolites[1][2][5]