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Target intelligence / Profile preview
Sulphonylurea receptor subunit SUR2B (SUR2B)
- Target
- SUR2B
- Molecular classification
- ATP-sensitive potassium (KATP) channel subunit, Ion channel subunit, Receptor subunit, ABCC family member
01
Overview
SUR2B is a regulatory subunit of the ATP-sensitive potassium (KATP) channel, crucial for linking cellular metabolism to electrical activity in smooth muscle and some neurons. It forms a hetero-octameric complex with Kir6.2 subunits and is involved in regulating muscle contraction and neuronal activity by modulating KATP channel activity in response to cellular energy status. Sulphonylureas can bind to SUR2B, but with lower affinity than SUR1.
02
Mechanism of action
Modulates KATP channel activity by binding ATP and ADP, and interacting with sulphonylureas. ATP hydrolysis by NBD2 affects channel gating.
03
Biological functions
Regulation of KATP channel activityLinking cellular metabolism to electrical activityRegulation of smooth muscle contractionModulation of neuronal activity
04
Disease associations
Type 2 diabetes (indirectly)Cardiovascular diseaseNeurological disorders
05
Safety considerations
Potential for off-target effects due to sequence similarity with other SUR isoformsRisk of hypoglycemia (with sulphonylurea use)
06
Interacting drugs
Sulphonylureas
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