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SUMO-activating enzyme subunit 1 (SAE1)
- Target
- SAE1
- Molecular classification
- Enzyme, E1 ubiquitin-like protein-activating enzyme, Ligase (E1 SUMO-activating enzyme)
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Overview
SUMO-activating enzyme subunit 1 (SAE1) is the regulatory subunit of the heterodimeric E1 enzyme complex responsible for activating SUMO (Small Ubiquitin-like Modifier) proteins, including SUMO1, SUMO2, SUMO3, and probably SUMO4[4][7]. SAE1 mediates ATP-dependent activation of SUMO, forming a heterodimer with SAE2 (UBA2), and catalyzes the initial step of the SUMOylation cascade—an essential post-translational modification that regulates protein localization, stability, and function[1][2][4][7]. SAE1 activity is crucial for processes such as chromosome segregation, apoptosis, and cellular stress responses. Dysregulation of SUMOylation and SAE1 expression is implicated in multiple pathologies, especially various cancers and inflammatory conditions[1][6]. SAE1 has potential as a therapeutic target and a biomarker in oncology and immunology[6].
- Other names
- AOS1HSPC140SUA1UBLE1ASAE1SUMO1 activating enzyme subunit 1
02
Mechanism of action
Inhibition of SUMOylation by blocking E1 enzyme activity
03
Biological functions
Post-translational modification (SUMOylation)Regulation of protein stabilityChromosome segregationCell cycle progressionApoptosisCellular stress response
04
Disease associations
CancerHepatocellular carcinomaGliomaColon cancerNon-small cell lung cancerRheumatoid arthritisOther
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Safety considerations
Potential effect on hematopoietic stem/progenitor cell survivalBroad impact on cellular homeostasis due to SUMOylation inhibition
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Biomarkers
Potential diagnostic biomarker for hepatocellular carcinomaMarker for glycolytic metabolism in rheumatoid fibroblast-like synoviocytes
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