SUMO-interacting motif-containing protein 1 (SIMC1)

SUMO-interacting motif-containing protein 1 (SIMC1) is a human protein encoded by the SIMC1 gene (also known as C5orf25, PLEIAD, OOMA1, FLJ44216). It contains multiple SUMO-interacting motifs (SIMs) enabling it to bind to SUMO polymers and associate with SUMO-rich bodies such as PML (promyelocytic leukemia) nuclear bodies. SIMC1 acts as a regulatory subunit for the SMC5/6 structural maintenance of chromosomes complex, particularly in the human antiviral response. Through its interaction with the SLF2 protein, SIMC1 forms an Nse5/6-like complex essential for SMC5/6 recruitment to sites of viral replication, thus helping restrict viral genome persistence. It also exhibits peptidase inhibitor activity. Mutations or alterations in SIMC1 are associated with rare diseases such as mucopolysaccharidosis type IIId and renal-hepatic-pancreatic dysplasia, and it may be involved in genomic stability mechanisms relevant to cancer and alternative telomere lengthening. There are currently no drugs or small molecules specifically known to target SIMC1, nor established biomarkers or safety concerns associated with its therapeutic targeting[2][3][4].

Other names

SUMO-interacting motif-containing protein 1SIMC1C5orf25PLEIADFLJ44216OOMA1Platform element for inhibition of autolytic degradationoocyte maturation associated 1

Not established for small molecule drugs (as of latest available data) SIMC1 recruits the SMC5/6 complex via SUMO-binding domains to sites of viral replication, restricting viral genome maintenance in mammalian cells[2][4]