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Superoxide Dismutase (SOD)
- Target
- SOD
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Superoxide dismutase (SOD) is a critical antioxidant enzyme found in virtually all living cells exposed to oxygen. Its primary function is to catalyze the dismutation of the superoxide anion radical (O2-) into molecular oxygen (O2) and hydrogen peroxide (H2O2), thereby protecting cells from oxidative damage caused by reactive oxygen species (ROS).
- Other names
- SOD1Cu/Zn-SODSOD2Mn-SODFe-SODNi-SODExtracellular SOD
02
Mechanism of action
Catalyzes the dismutation of superoxide radical into oxygen and hydrogen peroxide.
03
Biological functions
AntioxidantReactive oxygen species detoxificationMaintenance of cellular redox balanceRegulation of nitric oxide signaling
04
Disease associations
Amyotrophic lateral sclerosis (ALS)CancerNeurodegenerative disorders (Alzheimer’s disease, Parkinson’s disease)AgingInflammationIschemia-reperfusion injury
05
Safety considerations
Potential for disruption of redox balanceOff-target effects due to widespread expressionChallenges in delivering SOD to specific cellular compartments
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