Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Superoxide Dismutase Enzyme Family (SOD)
- Target
- SOD
- Molecular classification
- Enzyme, Metalloenzyme
01
Overview
Superoxide dismutases (SODs) are a family of metalloenzymes that catalyze the dismutation of the superoxide anion radical (O2-) into molecular oxygen (O2) and hydrogen peroxide (H2O2). This reaction is crucial for protecting cells from oxidative damage caused by reactive oxygen species (ROS). There are three main families/classes of SOD enzymes: Cu/Zn-SOD, Mn-SOD, and Fe-SOD/Ni-SOD, each with distinct metal cofactors and subcellular localizations. Mutations or dysregulation of human SODs have been linked with various diseases, including ALS and cardiomyopathy.
- Other names
- SOD1SOD2SOD3Cu/Zn-SODMn-SODFe-SODNi-SOD
02
Mechanism of action
Catalyzes the dismutation of superoxide anion radicals into molecular oxygen and hydrogen peroxide through redox cycling of a metal cofactor.
03
Biological functions
Antioxidant defenseRedox homeostasis regulationROS scavengingCell growth regulationCell differentiation regulationApoptosis regulationResponse to environmental stresses
04
Disease associations
Amyotrophic Lateral Sclerosis (ALS)CardiomyopathyOxidative stress-related diseases
05
Safety considerations
Potential for disruption of redox balanceOff-target effects of SOD-mimetic drugs
Beyond the preview
Go deeper on Superoxide Dismutase Enzyme Family (SOD).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Superoxide Dismutase Enzyme Family (SOD).