Superoxide Dismutase Mimic (SOD mimic)

Superoxide dismutase (SOD) mimics are synthetic compounds that replicate the catalytic activity of the native superoxide dismutase enzyme. They catalyze the conversion of superoxide anion (O2.-) into hydrogen peroxide (H2O2), mitigating oxidative stress and cellular damage. They are being explored for therapeutic applications in conditions where oxidative stress plays a key role, such as ischemia-reperfusion injury, neurodegenerative diseases, cardiovascular disorders, cancer, diabetes, and inflammatory bowel diseases. SOD mimics have advantages over native enzymes, including smaller size, better tissue penetration, greater chemical stability, and non-antigenic nature.

Other names

SOD mimeticsSOD/catalase mimetics

Catalyzes the dismutation of superoxide anion to hydrogen peroxide and oxygen: 2 O2.- + 2 H+ -> O2 + H2O2