Suppression of immunoactive and inflammatory cytokines

Suppression of immunoactive and inflammatory cytokines describes a therapeutic approach or physiological process in which molecules (such as drugs, endogenous regulatory proteins, or antibodies) decrease the production, signaling, or biological activity of cytokines that drive inflammation and immune cell activation. Cytokine suppression is clinically relevant in conditions characterized by excessive inflammation, such as autoimmune diseases, infections, and cytokine release syndrome. Drugs like corticosteroids, JAK inhibitors, and monoclonal antibodies targeting IL-6, IL-1, or TNF-α are used to achieve this suppression. This strategy is not linked to a unique molecular target, but rather involves multiple targets and pathways implicated in cytokine regulation and immune modulation.

Other names

Cytokine suppressionAnti-inflammatory cytokine regulationImmunomodulatory cytokine suppression

Inhibition of cytokine synthesis or release Blockade of cytokine receptors Inhibition of intracellular signaling pathways (e.g., JAK/STAT, NF-κB) Upregulation of anti-inflammatory mediators (e.g., IL-10, regulatory proteins)