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Target intelligence / Profile preview
Suppressor of cancer cell invasion protein (SCAI)
- Target
- SCAI
- Molecular classification
- Other, Transcriptional corepressor
01
Overview
The **suppressor of cancer cell invasion protein (SCAI)** is a transcriptional corepressor known to regulate cell migration and invasion, primarily through inhibition of the RhoA (Ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signaling pathway[4][1]. SCAI functions as a tumor suppressor by repressing MRTFA-induced (myocardin-related transcription factor A) SRF (serum response factor) transcriptional activity, influencing genes related to cell movement such as integrin ITGB1[4]. It is implicated in cancer biology, as its loss or dysfunction can promote tumor cell invasion and metastasis. SCAI is encoded by the C9orf126 gene and has several alternative names reflecting its identification in various studies and databases[4][2][5][6]. There are no known drug interactions, clinical biomarkers, or direct therapeutic targeting strategies for SCAI as of now.
- Other names
- C9orf126FLJ36664NET40Protein SCAIsuppressor of cancer cell invasion protein
02
Biological functions
Regulation of cell migrationTranscriptional repressionSignal transduction (RhoA-Dia1 pathway)Tumor suppression
03
Disease associations
Cancer
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