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Suppressor of Cytokine Signaling 3 (SOCS3)
- Target
- SOCS3
- Molecular classification
- Intracellular Signaling Protein, Transcription factor, Negative regulator of cytokine signaling
01
Overview
Suppressor of cytokine signaling 3 (SOCS3) is a protein that negatively regulates cytokine signaling, particularly through inhibition of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. It is induced by various cytokines and acts as part of a negative feedback loop to modulate immune responses and maintain cellular homeostasis. SOCS3 plays a role in various diseases, including type 2 diabetes, obesity, Alzheimer’s disease, immune disorders, and cancer.
- Other names
- CIS3Cish3SSI-3SSI3STAT-induced STAT inhibitor 3cytokine-inducible SH2 protein 3ATOD4
02
Mechanism of action
Inhibits JAK/STAT signaling by binding to JAKs or phosphotyrosine motifs on activated receptors, recruits E3 ubiquitin ligase complexes for targeted degradation.
03
Biological functions
Regulation of JAK/STAT signaling pathwayInhibition of cytokine signalingRegulation of immune cell activation and proliferationRegulation of insulin signaling
04
Disease associations
Type 2 DiabetesObesityAlzheimer’s DiseaseImmune DisordersCancerInflammation
05
Safety considerations
Dysregulation can lead to chronic inflammation or metabolic disturbances.May act as both a tumor suppressor or facilitator depending on context.
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