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Suppressor of Tumorigenicity 14 Protein (ST14)
- Target
- ST14
- Molecular classification
- Enzyme, Serine Protease, Type II transmembrane protein
01
Overview
Suppressor of tumorigenicity 14 protein (ST14), also known as matriptase, is a type II transmembrane serine protease that plays critical roles in tissue homeostasis, barrier function, and cancer biology. It is primarily expressed in epithelial tissues and exhibits trypsin-like serine protease activity. ST14 has context-dependent roles, acting as a tumor suppressor in some cases (e.g., colon cancer) and potentially promoting malignancy in others, depending on the tissue type and expression levels. Its activity is tightly regulated by endogenous inhibitors.
- Other names
- MatriptaseARCI11HAIMT-SP1MTSP1PRSS14SNC19TADG15TMPRSS14
02
Mechanism of action
Serine-type endopeptidase activity with specificity for basic amino acids
03
Biological functions
Epithelial barrier maintenanceActivation of other proteases/growth factorsEpidermal differentiationProteolysis
04
Disease associations
CancerInflammatory Bowel Disease
05
Safety considerations
Context-dependent role in tumorigenesis (tumor suppressor vs. promoter)Potential for off-target effects due to broad expression in epithelial tissues
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