Suppressor of tumorigenicity 20 protein (ST20)

Suppressor of tumorigenicity 20 protein (ST20) is a human protein thought to function as a tumor suppressor. It may promote apoptosis of cancer cells and is associated with cellular responses to genotoxic stress such as UV-C exposure. Alternative names reflect its discovery as a suppressor gene in cervical cancer. Its precise molecular mechanisms are not fully characterized, but it has been suggested to serve in apoptotic signaling pathways, possibly regulating cysteine-type endopeptidase activators. Aberrations including gene fusions or loss-of-function mutations may contribute to tumorigenesis, especially in carcinomas such as cervical cancer. Further research is required to establish its utility as a biomarker or a drug target, and to elucidate mechanisms relevant for therapeutic exploitation.

Other names

HCCS-1HCCS1Human cervical cancer suppressor gene 1 proteincervical cancer suppressor-1human cervical cancer suppressor 1human cervical cancer suppressor gene 1 proteinsuppressor of tumorigenicity 20 proteinST20