Suppressor of tumorigenicity 7 protein-like (ST7L)

Suppressor of tumorigenicity 7 protein-like (ST7L) is a gene product identified by its similarity to the ST7 tumor suppressor gene. It is clustered near WNT2B on the chromosome and frequently found to be downregulated in various cancers. ST7L exerts potent antitumor functions, suppressing cell proliferation, migration, and invasion by inhibiting Wnt/β-catenin signaling. Overexpression of ST7L increases cell adhesion molecules such as E-cadherin and reduces markers of EMT, thus restricting cancer cell metastatic potential. Although no drugs directly target ST7L, it represents an important molecule for future cancer therapy development.

Other names

ST7LSuppressor of tumorigenicity 7 protein-likeST7-related proteinFAM4BSTLRST7RFLJ20284

For potential drugs: restoration of ST7L function may suppress Wnt/β-catenin signaling, resulting in anti-tumor effects. Targeting pathways that modulate ST7L expression (e.g., miR-23a inhibits ST7L, reducing tumor suppressor activity). Indirect mechanisms via RNA interference or gene therapy (potential/future research).