Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Surfactant-associated protein B (SP-B)
- Target
- SP-B
- Molecular classification
- Saposins, Lipid Binding Proteins
01
Overview
Surfactant-associated protein B (SP-B) is a small, highly hydrophobic protein essential for lung function. It facilitates the spreading and stability of pulmonary surfactant, lowers surface tension, and prevents alveolar collapse. SP-B also plays a critical role in lipid organization, tubular myelin formation, and surfactant recycling. Deficiency or mutations in SP-B lead to severe neonatal respiratory distress syndrome and is universally lethal if untreated.
02
Mechanism of action
N/A
03
Biological functions
Surface tension reductionLipid organizationTubular myelin formationPulmonary surfactant homeostasis
04
Disease associations
Neonatal respiratory distress syndromeRespiratory failure
05
Safety considerations
Complete deficiency is lethal without intervention (lung transplantation or ECMO)Mutations can lead to severe respiratory distress
06
Biomarkers
SP-B levels in amniotic fluid or tracheal aspirates (for deficiency)
Beyond the preview
Go deeper on Surfactant-associated protein B (SP-B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Surfactant-associated protein B (SP-B).