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Target intelligence / Profile preview
Surfactant-associated protein C (SP-C)
- Target
- SP-C
- Molecular classification
- Pulmonary surfactant-associated protein
01
Overview
Surfactant-associated protein C (SP-C) is a small, highly hydrophobic membrane protein crucial for lung function. Encoded by the SFTPC gene, it's unique to pulmonary surfactant and essential for normal respiratory mechanics. It promotes alveolar stability by lowering surface tension at the air-liquid interface within the lungs.
- Other names
- SFTPCBRICD6PSP-CSFTP2SMDP2SP5surfactant protein C
02
Mechanism of action
N/A
03
Biological functions
Lowering surface tension in the lungsEnhancing adsorption and spreading of phospholipids at the air-liquid interfaceAlveolar stability
04
Disease associations
Familial interstitial pneumoniasChronic interstitial lung disease
05
Safety considerations
Mutations can lead to toxic gain-of-function effectsAbnormal processing can impair surfactant function
06
Biomarkers
SP-C levels in bronchoalveolar lavage fluid (potential)SFTPC mutations (diagnostic/prognostic)
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