Surfeit locus protein 2 (SURF2)

Surfeit locus protein 2 (SURF2) is a highly conserved protein encoded by the SURF2 gene in humans, located on chromosome 9q34.2, and is a member of the surfeit gene family[1][4][12]. SURF2 shares a bidirectional promoter with SURF1 and is expressed in a variety of tissues. Functionally, SURF2 interacts with beta-1,4-Gal-T3, uPAR, and WDR20, and acts as a key modulator of nucleolar stress response by binding free 5S ribonucleoprotein particles (5S RNP) but is not directly involved in ribosome assembly[2]. SURF2 buffers 5S RNP activity under basal conditions to prevent unnecessary activation of nucleolar stress, and its expression is implicated in tumorigenesis by influencing p53 activation during cellular stress[2]. Its precise function is not fully elucidated and no drugs or small molecules are documented to target SURF2 directly[2][10]. Additional notes & clarification: - SURF2 is not a classical therapeutic target such as a receptor, enzyme, transporter, or channel. It is best described as a *modulatory scaffold protein* involved in protein–RNA complex interactions[2][10]. - No known drugs, biomarkers, or safety concerns are directly associated with SURF2 as of current knowledge[2][10]. - Molecular and clinical understanding is still evolving, but increased expression and negative correlations with patient survival in certain cancers (e.g., adrenocortical carcinoma) have been documented, suggesting a possible disease relevance, though not yet as a direct drug target[2].

Other names

Surfeit 2Surf-2surfeit locus protein 2SURF-2