Survival of motor neuron 1, telomeric pseudogene (SMNP)

Survival of motor neuron 1, telomeric pseudogene (SMNP; ENSG00000237434) is a genomic sequence similar to the functional SMN1 gene but is classified as a pseudogene and does not produce a functional protein product[1][7]. Pseudogenes can regulate gene expression post-transcriptionally by acting as *microRNA decoys*, thus potentially modulating the expression of their protein-coding counterparts such as SMN1[3][5]. However, SMNP itself is not recognized as a gene of direct therapeutic interest, as it does not encode a protein or serve as a receptor, enzyme, transporter, or similar drug target. No clinically relevant drugs, biomarkers, or mechanisms of drug action are associated with this pseudogene.\n\nKey notes:\n- The canonical gene *SMN1* is therapeutically relevant (critical in spinal muscular atrophy), but SMNP is a non-coding pseudogene; it is not a therapeutic target[1][6].\n- There is no evidence that SMNP is directly implicated in disease or drug action, though similar pseudogenes may have regulatory effects.\n- SMNP is sometimes listed as \"Survival Of Motor Neuron 1, Telomeric (SMN1) Pseudogene\" in databases[1].\n- Pseudogenes like SMNP may modulate gene expression through non-coding RNA-mediated mechanisms, but this is an indirect effect[3][5].\n- The presence of \"pseudogene\" means it is not a conventional or actionable therapeutic target and thus typically should not be included in drug target panels.\n\nThis entry is *not* a standard or primary molecular drug target; if referenced in a therapeutic or pharmacological database as a target, this is likely incorrect or a result of annotation artifacts.

Other names

SMNPENSG00000237434Survival of Motor Neuron 1, Telomeric (SMN1) Pseudogene[1]