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Target intelligence / Profile preview
Survivin (BIRC5)
- Target
- BIRC5
- Molecular classification
- Inhibitor of Apoptosis (IAP) protein
01
Overview
Survivin, also known as BIRC5, is a protein that inhibits apoptosis and regulates cell division. It is highly expressed in embryonic development and most human tumors, but rarely detectable in differentiated adult tissues. Survivin is a member of the inhibitor of apoptosis (IAP) family. It plays a dual role in inhibiting programmed cell death and regulating cell division, making it a critical factor in cancer biology. It is an attractive target for anticancer therapies.
- Other names
- Baculoviral IAP Repeat Containing Protein 5
02
Mechanism of action
Antisense oligonucleotides bind to survivin mRNA, leading to its degradation and reduced survivin protein levels. Small molecule inhibitors directly bind to survivin and disrupt its function. Immunotherapies stimulate the immune system to target and kill cells expressing survivin.
03
Biological functions
Inhibition of ApoptosisRegulation of MitosisCell survival
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to structural similarity with other IAP proteinsDevelopment of drug resistanceComplex role in cell cycle regulation may lead to unforeseen consequences
06
Interacting drugs
Antisense oligonucleotides (targeting survivin mRNA)
2 more in the full profile.
07
Biomarkers
Survivin expression levels in tumor tissueSurvivin polymorphisms
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