Sushi domain-containing protein 2 (SUSD2)

Sushi domain-containing protein 2 (SUSD2) is a type I transmembrane protein with a large extracellular domain comprising several functional motifs (Sushi domains, somatomedin B, AMOP, and von Willebrand factor type D domains) typically found in cell adhesion and immune-related proteins[1][2][3]. It is highly expressed in several cancer types, notably breast cancer, where it may promote tumor cell invasion, angiogenesis, and immune evasion by interacting with the immune-modulatory protein Galectin-1. SUSD2 is being explored as a novel therapeutic target and biomarker for tumor detection and patient stratification, especially in breast cancer. Its full physiological function remains incompletely characterized, but it is implicated in cell adhesion, cell cycle regulation, and tissue specificity, with restricted expression in most normal adult tissues[2][3][1].

Other names

BK65A6.2FLJ22778W5C5testicular tissue protein Li 190sushi domain-containing protein 2sushi domain (SCR repeat) containing

Not established for any drug; however, antibody-based therapies targeting SUSD2 have been considered for cancer (mechanistically, such agents would target cell surface SUSD2 to mediate tumor cell killing)[2].