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Sushi domain-containing protein 5 (SUSD5)
- Target
- SUSD5
- Molecular classification
- Other (membrane protein with sushi domains; not classified as receptor, enzyme, transporter, etc.), Protein coding gene
01
Overview
Sushi domain-containing protein 5 is a human membrane protein encoded by the SUSD5 gene. The protein contains multiple “sushi domains”—structural domains commonly involved in protein–protein or glycan interactions. It is predicted to bind hyaluronic acid via a specialized “link domain” and may play a role in the Notch signaling pathway, although its precise molecular function is unresolved. SUSD5 has been identified as differentially expressed in some cancer proteomic studies, but is not currently established as a therapeutic or diagnostic target, and no interacting drugs or known biomarkers are reported. Diseases associated with SUSD5 include Sneddon syndrome and several cancers based on indirect network analyses.
- Other names
- SUSD5KIAA0527Sushi domain containing 5Gm1126RGD1561132
02
Biological functions
Hyaluronic acid bindingInvolvement in Notch signaling pathway (predicted)Binding (general protein function, not specific)
03
Disease associations
Cancer (associated protein differentially expressed in cancer proteomics studies)Sneddon syndrome (associated disease annotation, but mechanistic link unclear)Organismal injury and abnormalities, reproductive system disease, endocrine system disorders, neurological disease (network-level associations, not direct mechanistic roles)
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