Sushi repeat-containing protein X-linked (SRPX)

Sushi repeat-containing protein X-linked (SRPX) is an extracellular matrix protein encoded by the SRPX gene on chromosome Xp11.4[2][8]. The protein contains multiple sushi (complement control protein) domains, a peroxiredoxin-like P-DUDES domain, and is implicated in cell adhesion, membrane interactions, and potentially redox regulation[6][8][9]. SRPX has tumor suppressor properties and is associated with various human cancers, where it may be downregulated or functionally altered[2][4]. It participates in intercellular communication and extracellular matrix organization, potentially influencing cancer progression, metastasis, and tissue architecture[2][4][8][9]. The protein may serve as a biomarker for disease prognosis but currently lacks specific approved therapeutic drugs or safety data regarding direct inhibition or activation[4][9].

Other names

DRSETX1SRPX1HEL-S-83psushi repeat-containing protein SRPXepididymis secretory sperm binding protein Li 83p

No established drugs; hypothetical mechanisms could involve inhibition or modulation of its function in the extracellular matrix or cell adhesion, or targeting the P-DUDES domain's putative enzymatic or redox activity