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Target intelligence / Profile preview
SWELL1 chloride channel complex
- Molecular classification
- Leucine-rich repeat containing proteins, Ion channel
01
Overview
SWELL1, also known as LRRC8A, is a protein that forms the core of the volume-regulated anion channel (VRAC). VRACs are critical for maintaining cellular homeostasis by regulating cell volume in response to osmotic changes. SWELL1 can form homo-hexameric channels but typically assembles with other LRRC8 family members (LRRC8B-E) to create heteromeric VRAC complexes, which dictates the biophysical properties and selectivity of the channel. It plays a role in metabolic regulation, cell survival under osmotic stress, and is associated with diseases such as metabolic syndrome and immunodeficiency.
- Other names
- LRRC8A
02
Mechanism of action
Modulation of chloride ion flux across cell membranes in response to changes in cell volume and ionic strength.
03
Biological functions
Cell volume regulationOsmosensingSignal transductionChloride transport
04
Disease associations
Metabolic syndromeImmunodeficiency
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