SWI5-dependent HO expression protein 2 (She2p)

SWI5-dependent HO expression protein 2 (She2p) is a non-canonical RNA-binding protein from the budding yeast Saccharomyces cerevisiae that is fundamental to the study of intracellular mRNA transport [1, 6]. It acts as a central component of the 'locasome,' a ribonucleoprotein complex responsible for the asymmetric localization of mRNAs, most notably ASH1 mRNA, to the bud tip of dividing yeast cells [1, 2, 4]. She2p functions as a tetramer that recognizes specific 'zipcode' stem-loop structures in the 3' untranslated region of target mRNAs and recruits the Myo4p–She3p motor-adaptor complex for transport along actin filaments [6, 16, 17]. This protein is an essential model for understanding how cells spatially regulate gene expression, though it has no known human ortholog and is not a recognized therapeutic target in clinical medicine [1, 3, 12]. While some research suggests that disrupting fungal mRNA transport systems could represent a novel strategy for antifungal development, She2p specifically is absent in major human pathogens like Candida albicans, which utilize different adaptor proteins for similar processes [12]. In a pharmaceutical or biotech context, 'She2 protein' is frequently an incorrect reference, often resulting from a typo for established human targets such as SHP2 (PTPN11) or HER2 (ERBB2), or an error in parsing scientific citations where 'She' is an author name and '2' refers to an institutional affiliation [10, 13].

Other names

She2YKL130CSwi5-dependent HO expression 2 protein

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