Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
SWIM-type zinc finger 7 associated protein 1 (SWSAP1)
- Target
- SWSAP1
- Molecular classification
- Enzyme (ATPase), DNA-binding protein, RAD51 paralogue, Zinc finger protein (SWIM-type domain), Shu complex member
01
Overview
SWIM-type zinc finger 7 associated protein 1 (SWSAP1) is a member of the RAD51 paralogue family that possesses an ATPase activity preferentially stimulated by single-stranded DNA. SWSAP1 is a component of the human Shu complex (including SWS1), which promotes and stabilizes RAD51 filament assembly during homologous recombination-mediated DNA repair. SWSAP1 antagonizes anti-recombinase FIGNL1, thereby protecting RAD51 filaments from premature disassembly and facilitating efficient DNA repair. Mutation or deficiency in SWSAP1 impairs DNA repair via homologous recombination, potentially leading to genomic instability and increased risk for certain cancers. SWSAP1 contains a SWIM-type zinc finger domain and interacts with DNA and key proteins in the recombination machinery.
- Other names
- ATPase SWSAP1C19orf39ZSWIM7AP1FLJ35119SWS1-associated protein 1ZSWIM7-associated protein 1Zinc finger, SWIM-type containing 7 associated protein 1SWIM-type zinc finger 7-associated protein 1
02
Mechanism of action
Not directly drug-targeted; SWSAP1 acts by facilitating RAD51 filament assembly, stabilizing RAD51 during homologous recombination, and antagonizing anti-recombinase FIGNL1.
03
Biological functions
Double-strand break repair via homologous recombinationProtein stabilization (RAD51 filament)Single-stranded DNA bindingATP hydrolysisRegulation of DNA damage repair
04
Disease associations
Hereditary breast ovarian cancer syndrome (indirect role via homologous recombination/DNA repair)Gonadal dysgenesis (dysfunction in repair)Potential roles in cancer predisposition (through genome stability/DNA damage repair)Other DNA repair-related diseases
05
Safety considerations
None reported for targeting SWSAP1 directly. However, modulation of homologous recombination repair pathways, where SWSAP1 acts, carries potential risks of genome instability and cancer predisposition if disrupted.
06
Interacting drugs
None directly established or approved. While SWSAP1 is mechanistically involved in DNA repair, no drugs specifically target SWSAP1 as of current scientific literature.
07
Biomarkers
No established clinical biomarkers for patient selection or efficacy monitoring directly related to SWSAP1. Activity or levels of SWSAP1 may correlate with homologous recombination proficiency and genome stability, which are relevant in cancer susceptibility and response to DNA damaging agents.
Beyond the preview
Go deeper on SWIM-type zinc finger 7 associated protein 1 (SWSAP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on SWIM-type zinc finger 7 associated protein 1 (SWSAP1).