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Sympathetic Autonomic Nervous System (SNS)
- Target
- SNS
- Molecular classification
- Nervous System Division
01
Overview
The sympathetic autonomic nervous system (SNS) is a division of the autonomic nervous system responsible for preparing the body for "fight-or-flight" responses. It increases heart rate, blood pressure, respiration, and glucose mobilization while decreasing digestion and urination. Its primary neurotransmitters are norepinephrine and epinephrine. Imbalance in SNS activity is implicated in various cardiovascular, metabolic, and neuropsychiatric disorders.
- Other names
- Sympathetic Nervous SystemThoracolumbar outflow
02
Mechanism of action
Varies depending on the specific drug and its target within the SNS (e.g., blocking adrenergic receptors, inhibiting neurotransmitter release).
03
Biological functions
Fight-or-flight responseStress responseRegulation of heart rateRegulation of blood pressureRegulation of respirationRegulation of pupil sizeRegulation of sweatingRegulation of digestionRegulation of urinationGlucose mobilization
04
Disease associations
HypertensionArrhythmiasAnxiety disordersMetabolic syndromeCardiovascular diseaseSudden death
05
Safety considerations
Orthostatic hypotensionBradycardiaBronchospasmCardiac arrhythmias
06
Interacting drugs
Beta-blockers
3 more in the full profile.
07
Biomarkers
Heart rate variabilityPlasma norepinephrine levelsPlasma epinephrine levels
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