Synapse-associated protein 1 (SYAP1)

Synapse-associated protein 1 (SYAP1) is a BSD domain-containing adaptor protein that interacts with signaling partners such as Akt1, promoting phosphorylation of Akt1 at Ser477 in a process facilitated by mTORC2, and is involved in cellular response to growth factors including epidermal growth factor and peptide hormones[1][3]. This phosphorylation event is implicated in adipocyte differentiation by suppressing FoxC2 expression[1]. In mammals, SYAP1’s most prominent expression is within the nervous system, particularly in cerebellar Purkinje cells and cerebellar nuclei, as well as throughout regions rich in glutamatergic synapses[2]. Knockout mouse studies show that loss of SYAP1 results in distinct locomotor and motor adaptation defects, but does not affect basic metabolic parameters, cognition, or general viability. The gene is located on Xp22.2, a locus associated with neurodevelopmental disorders, with mutations in humans linked to developmental delay and autism spectrum[2][3]. Functionally, SYAP1 is not a receptor, enzyme, transporter, or classic drug target, but serves as a scaffold/adaptor implicated in signaling and neuronal function[1][2][3].

Other names

BSTAPRO3113FLJ14495BSD domain-containing signal transducer and Akt interactor proteinSAP47 homolog (Drosophila)SAP47 homologsynapse associated protein 1