Synapse defective Rho GTPase homolog 2 (SYDE2)

Synapse defective Rho GTPase homolog 2 (SYDE2) is an enzyme of the RhoGAP family found primarily in the cytosol and synaptic membrane, where it acts as a GTPase activator for Rho-type GTPases by converting them to an inactive GDP-bound state[3][5][8]. SYDE2 contains conserved C2 and RhoGAP domains, mediating its role as a regulator of actin cytoskeleton dynamics, neuronal differentiation, and signaling during embryonic brain development[1][6]. Predicted protein-protein interaction sites and phosphorylation motifs are conserved, supporting a dynamic regulatory role in synaptic scaffolding and neuronal signaling complexes[1]. Disease-associated mutations (e.g., truncations) in SYDE2 can affect brain development or neurodevelopmental outcomes[1][3]. No approved drugs specifically interact with SYDE2, and the lack of crystal structure information currently limits structure-based drug discovery opportunities[1][8].

Other names

Rho GTPase-activating protein SYDE2Synapse defective protein 1 homolog 2Protein syd-1 homolog 2FLJ13815Synapse defective protein 1 homolog 2, protein syd-1 homolog 2, synapse defective 1SYDE2