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Synapse differentiation-inducing gene protein 1-like (SYNDIG1L)
- Target
- SYNDIG1L
- Molecular classification
- Transmembrane protein, Dispanin family (specifically subfamily C), Other
01
Overview
Synapse differentiation-inducing gene protein 1-like (SYNDIG1L) is a human transmembrane protein encoded by the SYNDIG1L gene, also known as TMEM90A, Capucin, and other aliases[8][6]. SYNDIG1L is predicted to be located in cellular membranes and the Golgi apparatus, similar to other dispanin family members. Its biological function is not fully characterized; however, it is closely related to SYNDIG1, which regulates AMPA receptor content and is involved in synapse maturation and development in the brain[1]. Currently, there is no direct evidence linking SYNDIG1L itself as a therapeutic target or receptor for drugs, nor are there established interacting drugs, biomarkers, or safety concerns associated with this protein[8]. Diseases genetically associated with SYNDIG1L include osteogenesis imperfecta and ovary sarcoma[8].
- Other names
- TMEM90ADSPC1CapucinIFITMD4SynDIG2Dispanin subfamily C member 1Transmembrane protein 90Acaudate-and putamen-enriched sequenceinterferon induced transmembrane protein domain containing 4
02
Biological functions
Postsynaptic development and maturationRegulation of excitatory synapse developmentPossible regulation of AMPA receptor delivery at developing synapsesGlutamate receptor bindingProtein homodimerization activity
03
Disease associations
Osteogenesis imperfectaSarcoma (specifically ovary sarcoma)Other (no known major therapeutic target association)
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