Synaptic vesicle 2-related protein (SVOP)

Synaptic vesicle 2-related protein (SVOP) is a non-glycosylated, transporter-like membrane protein distantly related to the synaptic vesicle glycoprotein 2 (SV2) family, sharing 20–22% sequence homology[1][5]. Like SV2, SVOP has a predicted 12-transmembrane domain structure and is a member of the major facilitator superfamily of transporters, but it is classified as a distinct protein family[1][3][5]. SVOP is localized to neurotransmitter-containing synaptic vesicles and binds nucleotides, showing a particular affinity for NAD and ATP, although the precise physiological function of this nucleotide binding remains undefined[3][5]. While SV2 proteins are directly involved in calcium-dependent neurotransmitter release and constitute recognized drug targets, SVOP's functional roles are less characterized; current evidence supports involvement in synaptic vesicle biology but not in classical neurotransmitter or ion transport[1][3][5]. There are no clinically validated drugs known to target SVOP, and it does not serve as a common biomarker or established disease target in human medicine as of current knowledge[1][3][5].

Other names

SV2-related proteinDKFZp761H039SLC22B4solute carrier family 22 member B4SV2 related protein homologSVOP