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Synaptic Vesicle Glycoprotein 2A
- Molecular classification
- Keratan sulfate proteoglycans, Transmembrane protein
01
Overview
Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein located on synaptic vesicles in mammalian neuronal and endocrine cells. It is present in all synaptic terminals and plays a key role in regulating neurotransmitter release at synapses. It modulates synaptic vesicle exocytosis and endocytosis. Alterations or dysfunctions involving SV2A have been implicated in epilepsy and neurodegenerative conditions.
02
Mechanism of action
The precise mechanism by which levetiracetam and brivaracetam affect or modulate the function of SV2A remains unclear. They bind selectively to SV2A and are effective anticonvulsants.
03
Biological functions
Neurotransmitter release regulationSynaptic vesicle exocytosis and endocytosisCalcium homeostasisMarker for synapse density
04
Disease associations
EpilepsyNeurodegenerative disease
05
Safety considerations
Precise mechanism of action for drugs targeting SV2A is unclear.
06
Interacting drugs
Levetiracetam
1 more in the full profile.
07
Biomarkers
Synaptic density marker (using PET imaging)
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