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Target intelligence / Profile preview
Synaptic vesicle glycoprotein 2C (SV2C)
- Target
- SV2C
- Molecular classification
- Major facilitator superfamily (MFS), SLC22B family, Transporter
01
Overview
SV2C is a critical synaptic vesicle protein predominantly expressed in dopaminergic regions of the brain. It regulates neurotransmitter storage—especially dopamine—by modulating uptake/retention within presynaptic vesicles. Its interactions with key proteins like synaptotagmin‑1 and α-synuclein link it directly to exocytosis processes and neurodegenerative disease pathways such as those seen in Parkinson's disease. Additionally, its role as a receptor for botulinum toxins highlights its clinical relevance beyond endogenous physiology. Despite extensive research, many aspects—including precise transport substrates—remain incompletely understood at this time.
02
Mechanism of action
N/A
03
Biological functions
Neurotransmitter transportSynaptic vesicle traffickingRegulated secretionDopamine uptake/retention
04
Disease associations
Parkinson’s DiseaseAlzheimer’s DiseaseAutism Spectrum DisordersNeurological Disorders
05
Safety considerations
Potential for off-target effects due to sequence similarity with other SV2 isoformsIncomplete understanding of precise transport substrates
06
Interacting drugs
Botulinum neurotoxin A (BoNT/A)
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