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Target intelligence / Profile preview
Synaptic Vesicle Protein 2A (SV2A)
- Target
- SV2A
- Molecular classification
- Transporter, Solute carrier (SLC22) family, Glycoprotein
01
Overview
Synaptic vesicle protein 2A (SV2A) is a transmembrane glycoprotein located on the membrane of synaptic vesicles in mammalian neuronal and endocrine cells. It plays a crucial role in regulating neurotransmitter release at synapses by modulating synaptic vesicle exocytosis and interacts with synaptotagmin. Deficiency or dysfunction of SV2A has been linked to neurological disorders including epilepsy, schizophrenia, and Alzheimer’s disease. It is also the molecular target for antiepileptic drugs like levetiracetam and brivaracetam.
- Other names
- Synaptic Vesicle Glycoprotein 2aSVP38
02
Mechanism of action
Stabilizes an inhibited conformation of the transporter-like protein, reducing neuronal activity.
03
Biological functions
Regulation of neurotransmitter releaseModulation of exocytosisModulation of endocytosisVesicular traffickingCalcium-mediated neurotransmitter releaseEnergy modulation
04
Disease associations
EpilepsySchizophreniaAlzheimer’s disease
05
Interacting drugs
Levetiracetam
1 more in the full profile.
06
Biomarkers
Presynaptic density (PET imaging)
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