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Target intelligence / Profile preview
Synaptic Vesicular Amine Transporter (VMAT)
- Target
- VMAT
- Molecular classification
- Transporter, Major Facilitator Superfamily (MFS)
01
Overview
The synaptic vesicular amine transporter (VMAT), also known as the vesicular monoamine transporter, is a membrane protein responsible for transporting monoamine neurotransmitters (dopamine, serotonin, norepinephrine, epinephrine, and histamine) from the cytosol into synaptic vesicles within neurons. This process is essential for the storage and regulated release of these neurotransmitters during synaptic transmission. VMATs function as antiporters, using a proton gradient to accumulate monoamines inside storage granules or synaptic vesicles for rapid release upon neuronal stimulation. Dysfunction or inhibition of VMAT activity has been implicated in various neurological disorders including Parkinson’s disease and drug addiction.
- Other names
- Vesicular Monoamine Transporter
02
Mechanism of action
Proton antiport; uses H+ gradient to transport monoamines into vesicles
03
Biological functions
Neurotransmitter transportNeurotransmitter storageRegulation of synaptic transmissionMonoamine homeostasis
04
Disease associations
Parkinson's DiseaseDrug AddictionMood disordersMovement disordersNeurodegenerative disease
05
Safety considerations
Monoamine depletion (e.g., with reserpine)Effects on mood and movement
06
Interacting drugs
Reserpine
07
Biomarkers
VMAT2 (imaging marker for dopaminergic neurons)
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