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Target intelligence / Profile preview
Synaptic Vesicular Amine Transporter 1 (VMAT1)
- Target
- VMAT1
- Molecular classification
- Solute Carrier, Transporter, Membrane Protein
01
Overview
Synaptic vesicular amine transporter 1 (VMAT1) is a membrane-embedded protein responsible for transporting monoamine neurotransmitters into synaptic vesicles within neurons. This process is essential for the storage and subsequent regulated release of neurotransmitters such as dopamine, serotonin, norepinephrine, epinephrine, and histamine into the synaptic cleft during neurotransmission. It is encoded by the SLC18A1 gene and belongs to the solute carrier family 18 (SLC18).
- Other names
- Vesicular Monoamine Transporter 1SLC18A1
02
Mechanism of action
Monoamine transport into synaptic vesicles
03
Biological functions
Neurotransmitter transportMonoamine storageVesicular transportRegulation of neurotransmission
04
Disease associations
Psychiatric disordersNeurological disorders
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