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Target intelligence / Profile preview
Synaptic Vesicular Amine Transporter 2 (VMAT2)
- Target
- VMAT2
- Molecular classification
- Transporter, Integral membrane protein
01
Overview
VMAT2, or Vesicular Monoamine Transporter 2, is an integral membrane protein encoded by the SLC18A2 gene. It transports monoamine neurotransmitters (dopamine, serotonin, norepinephrine, epinephrine, and histamine) from the cellular cytosol into synaptic vesicles. VMAT2 plays a critical role in neurotransmitter storage, release, and protection from autoxidation. It is expressed in both central and peripheral nervous systems and is implicated in neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. VMAT2 is a target for drugs like tetrabenazine, used in treating Huntington's chorea, and is also affected by drugs of abuse like amphetamine and MDMA.
- Other names
- Vesicular monoamine transporter 2SLC18A2
02
Mechanism of action
Non-competitive inhibition of VMAT2 leading to reduced monoamine transport into synaptic vesicles.
03
Biological functions
Neurotransmitter transportNeurotransmitter storageNeurotransmitter releaseProtection from autoxidation
04
Disease associations
Parkinson's diseaseSchizophreniaHuntington's disease
05
Safety considerations
Side effects associated with VMAT2 inhibitors
06
Interacting drugs
Tetrabenazine
2 more in the full profile.
07
Biomarkers
VMAT2 expression levels as a diagnostic marker
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