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Synaptogyrin-1 (SYNGR1)
- Target
- SYNGR1
- Molecular classification
- Integral membrane protein, Presynaptic vesicle protein, Synaptogyrin family, Other (not a receptor, transporter, enzyme, ion channel, or transcription factor)
01
Overview
Synaptogyrin-1 is an integral membrane protein localized to presynaptic vesicles in neuronal cells. It belongs to the synaptogyrin family and is implicated in modulating synaptic plasticity, exocytosis, and vesicle trafficking. The gene is located on chromosome 22q13.1 and produces several transcript variants. Although the exact molecular function remains unclear, studies in animal models suggest its role in regulating synaptic structure and function. Genetic mutations and polymorphisms in SYNGR1 are associated with increased susceptibility to neuropsychiatric disorders such as schizophrenia and bipolar disorder, making it a candidate gene for research in these pathologies.
- Other names
- SYNGR1Synaptogyrin 1Synaptogyrin-1synaptogyrin-1
02
Mechanism of action
Not applicable, as no drugs target this molecule directly
03
Biological functions
Synaptic plasticityModulation of synaptophysin localization into synaptic-like microvesiclesRegulated exocytosisNeuronal vesicle traffickingMay be involved in presynaptic pathways relevant for neuropsychiatric function
04
Disease associations
Neuropsychiatric disease (gene variants associated with susceptibility to schizophrenia and bipolar disorder)Other (altered expression linked to abnormal synaptic function; not directly implicated in cancer, inflammation, cardiovascular disease, or infection)
05
Biomarkers
Genetic variants in SYNGR1 are used in research as potential biomarkers of susceptibility for neuropsychiatric conditions such as schizophrenia and bipolar disorderExpression levels may be studied in patient tissue as a research biomarker
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