Synaptogyrin 2 pseudogene

Synaptogyrin 2 pseudogene (ENSG00000233457) is a nonfunctional genomic element that has high sequence similarity to the functional synaptogyrin 2 gene but contains sequence disruptions (such as premature stop codons or frameshifts) and does not encode a functional protein. Pseudogenes are generally incapable of producing functional protein products and are classified based on their genomic origin; the synaptogyrin 2 pseudogene is likely a processed pseudogene, which arises from reverse transcription of mRNA and reintegration into the genome without regulatory components necessary for expression[1][3][5][7]. This entry is not a protein-coding gene or a functional protein but a "pseudogene", meaning it resembles a functional gene (in this case, synaptogyrin 2) but lacks the ability to produce a functional protein due to disruptions in its sequence[3][5][7]. Pseudogenes are not considered bona fide therapeutic targets for drug discovery or intervention and do not participate in physiological processes, molecular functions, disease mechanisms, or therapeutic pathways in the same way as active genes or receptors[1][5][7]. There is an actual protein-coding gene called Synaptogyrin 2 (SYNGR2, ENSG00000108639) that has biological roles in membrane trafficking, exocytosis, and viral infection pathways[2][4][6], but this is not the same as the pseudogene entry queried here. The synaptogyrin 2 pseudogene (ENSG00000233457) is a nonfunctional DNA sequence and not a valid therapeutic or research target[1][3][5][7]. For functional studies, refer to the protein-coding gene "Synaptogyrin 2" (SYNGR2, ENSG00000108639)[6].

Other names

Synaptogyrin 2 (SYNGR2) pseudogeneENSG00000233457