Synaptogyrin-3 (SYNGR3)

Synaptogyrin-3 is an integral membrane protein predominantly localized to synaptic vesicles in the brain. It is essential for proper dopaminergic neurotransmission and forms complexes with the dopamine transporter (DAT) and vesicular monoamine transporter-2 (VMAT2), allowing efficient coupling of dopamine reuptake with vesicular storage. This protein supports the maintenance of synaptic vesicle morphology, cooperates with membrane lipids to facilitate synaptic vesicle membrane remodeling, and is regulated transcriptionally by the nuclear receptor NURR1. Pathologically, impaired SYNGR3 expression is implicated in neurodegenerative disorders such as Parkinson’s disease and is a clinically useful biomarker in HPV-positive head and neck cancers for both diagnosis and prognosis.

Other names

Synaptogyrin 3SYNGR3SNG3SNG3_HUMAN

Drugs or compounds targeting SYNGR3 would likely alter synaptic dopamine transporter (DAT) activity and vesicular dopamine storage. VMAT2 inhibitors (e.g., reserpine) can block SYNGR3-mediated DAT regulation by disrupting vesicular dopamine storage.