Synaptojanin 2 (SYNJ2)

Synaptojanin 2 (SYNJ2) is an enzyme of the inositol-polyphosphate 5-phosphatase family that regulates membrane trafficking and signal transduction by hydrolyzing phosphoinositides, specifically removing the 5-phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and phosphatidylinositol (4,5)-bisphosphate (PIP2)[1][3][4]. This activity is involved in early steps of clathrin-mediated endocytosis, the formation of invasive cellular structures called invadopodia (especially in cancer cells), and the regulation of various protein complexes through its multiple binding domains. Unlike the primarily neural SYNJ1, SYNJ2 is expressed in a wide range of tissues and has multiple alternative splice variants. It is implicated in cancer, certain neurodevelopmental syndromes, and possibly in other pathologies via its regulatory role on phosphoinositide metabolism and vesicle dynamics[1][3][4].

Other names

KIAA0348INPP5HSynaptic inositol 1,4,5-trisphosphate 5-phosphatase 2phosphoinositide 5-phosphataseinositol polyphosphate-5-phosphatase Hsynaptojanin-2inositol phosphate 5'-phosphatase 2

Drugs would act as inhibitors or activators of phosphoinositide 5-phosphatase enzymatic activity, alter endocytosis or signaling pathways, or modulate invasion-mediated processes[1][4].