Synaptojanin-2-binding protein (SYNJ2BP)

Synaptojanin-2-binding protein (SYNJ2BP) is a mitochondrial outer membrane protein with a PDZ domain, acting as a scaffold/adaptor involved in multiple cellular pathways. It regulates mitochondrial morphology, supports neuronal energy supply by controlling mitochondrial transport in motor neurons, and influences mitochondrial–ER contact sites. SYNJ2BP participates in endocytosis of activin type II receptors, modulates Notch signaling by stabilizing Notch ligands, and interacts with various membrane and cytoskeletal proteins. Reduction or dysfunction of SYNJ2BP is associated with enhanced tumor growth and invasiveness in hepatocellular carcinoma and increased susceptibility to neurodegenerative diseases such as ALS. SYNJ2BP is considered both a potential therapeutic target and disease biomarker in oncology and neurology[1][2][4][5][7][8].

Other names

Synaptojanin-2-binding proteinSYNJ2BPOMP25ARIP2Mitochondrial outer membrane protein 25Activin receptor interacting protein 5

Not targeted by approved drugs as of current knowledge; mechanisms include modulation of receptor stability, trafficking, and signal transduction pathways such as PI3K/AKT and MAPK (in cancer and neuronal cells)[2][5]