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Target intelligence / Profile preview
Synaptonemal complex central element protein 2 (SYCE2)
- Target
- SYCE2
- Molecular classification
- Other (Structural protein of the synaptonemal complex)
01
Overview
Synaptonemal complex central element protein 2 (SYCE2) is a major structural component of the central element of the synaptonemal complex, a tripartite protein assembly that physically links paired homologous chromosomes during meiotic prophase I[5][6]. SYCE2 forms highly stable hetero-oligomeric complexes (notably as a tetramer and in an octameric complex with TEX12), which polymerize to reinforce the longitudinal structure of the synaptonemal complex[1][2][7]. It is essential for proper synapsis and fertility, but is not currently considered a target for therapeutic drugs[1][5][3][6]. There are no known drugs or biomarkers associated with SYCE2, and it is not classified as a receptor, enzyme, or transporter but rather as a structural chromosome-associated protein crucial for meiotic cell division[1][5][6].
- Other names
- CESC1Central element synaptonemal complex protein 1Synaptonemal complex central element protein 2SYCE2
02
Biological functions
Chromosome synapsis during meiosisStructural assembly of the synaptonemal complex
03
Disease associations
Other (No established direct role in major diseases; rare genetic findings relate to meiotic defects; associations such as Glutaric Acidemia I are listed but mechanistic links are unclear)
04
Safety considerations
Disruption could lead to meiotic failure and infertility; no therapeutic targeting or safety data available
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