Synaptonemal complex protein 2-like (SYCP2L)

SYCP2L (Synaptonemal complex protein 2-like) is an oocyte-specific nuclear protein homologous to SYCP2, primarily expressed in female germ cells during early ovarian follicle development[1][3]. It localizes to centromeres at the dictyate stage of oocytes, playing a key role in preserving the pool of primordial oocytes and regulating female reproductive aging[1]. Loss of SYCP2L leads to a rapid depletion of ovarian reserves and reduced fertility in mice[1]. In humans, SYCP2L gene variants, especially intronic SNP rs2153157, are associated with differences in age at natural menopause, likely by affecting splicing efficiency and transcript levels[1]. There is no current evidence of SYCP2L being a drug target, nor are there known direct interactions with clinical molecules. Its principal biological significance is as a molecular preservation factor for oocytes and ovarian lifespan.

Other names

SYCP2LSynaptonemal complex protein 2-like145 kDa nucleolar protein homologC6orf177NO145SCP-2-likehsNO145dJ62D2.1POF24

None known for drugs. (SYCP2L has not been directly targeted pharmacologically.)