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Synaptonemal complex protein 3 (SYCP3)
- Target
- SYCP3
- Molecular classification
- Other
01
Overview
Synaptonemal complex protein 3 (SYCP3) is a structural protein required for the formation and stabilization of the lateral elements of the synaptonemal complex during meiosis. SYCP3 forms highly elongated, helical tetramers that bind DNA via their N-terminal regions, enabling looping and compaction of homologous chromosomes to support proper recombination and crossover formation during gametogenesis. SYCP3 self-assembles into filamentous higher-order structures along the chromosome axis, in cooperation with other synaptonemal complex constituents. It is not considered a classical drug target, but its dysregulation has been linked to infertility and cancer due to disruption of normal chromosome segregation and DNA repair pathways[1][3].
- Other names
- COR1
02
Biological functions
Meiotic chromosome organizationChromosome pairing/synapsisChromosome compactionHomologous recombination facilitation
03
Disease associations
Cancer (ectopic expression in somatic cells linked to tumorigenesis)Infertility (essential for meiosis/fertility)
04
Safety considerations
Aberrant expression in somatic cells can impair DNA repair and promote aneuploidy
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