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Target intelligence / Profile preview
Synaptoporin (Synpr)
- Target
- Synpr
- Molecular classification
- Integral membrane protein, MARVEL domain family member, Vesicular channel protein
01
Overview
Synaptoporin is a 37 kDa integral membrane protein located on synaptic vesicles, sharing high sequence and structural similarity with synaptophysin but possessing a divergent cytoplasmic tail[2][3]. It is a member of the MARVEL (MAL and Related proteins for VEsicle trafficking and membrane Link) domain family, with four conserved transmembrane domains and high expression in the central nervous system. Synaptoporin forms part of a family of vesicular channel proteins that may contribute to synaptic vesicle membrane organization, transporter or channel activity, and protein–protein interactions during neurotransmitter release. Though synaptoporin is not a therapeutic target, it is used to distinguish subpopulations of synaptic vesicles and as an anatomical CNS marker in some research contexts[2][3][4].
- Other names
- Synaptophysin-2Synpr protein, rat
02
Mechanism of action
None known (no established mechanisms involving pharmacological modulation of synaptoporin)
03
Biological functions
Synaptic vesicle membrane organizationPutative ion channel or transporter in synaptic vesiclesMay interact with vesicle sorting machinery (e.g., V-ATPase, synaptobrevin)Involved in synaptic vesicle subpopulation distribution
04
Disease associations
Other (No reports directly linking synaptoporin with specific diseases; studies focus on expression and structural role within synaptic vesicles and its use as a neuronal marker)
05
Safety considerations
None known (structure and localization suggest low risk for direct safety concerns, as it is not a drug target)
06
Interacting drugs
None known (no approved drugs shown to directly interact with synaptoporin)
07
Biomarkers
Sometimes used as a neuronal marker for small synaptic vesicles; involved in neuroanatomical or injury-related studies
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