Synaptosomal-associated protein 23 (SNAP23)

Synaptosomal-associated protein 23 (SNAP23) is a ubiquitously expressed **plasma membrane-localized SNARE protein** (Soluble NSF Attachment Protein Receptor), structurally and functionally related to SNAP25, but unlike SNAP25, is present in most tissues rather than being neuron-specific[1][2][3][4]. SNAP23 plays a central role in regulating **membrane fusion events**, including exocytosis, endocytosis, and phagocytosis, by forming multipartite SNARE complexes with syntaxins (target membrane SNAREs) and synaptobrevins/VAMPs (vesicle SNAREs)[1][2][3][4]. It is essential for transport vesicle docking and fusion, influencing crucial cellular processes in immune cells (such as phagosome formation in macrophages) and metabolic tissues (such as insulin-regulated GLUT-4 vesicle trafficking in adipocytes and muscle)[1][2][3][4]. SNAP23 function is regulated by post-translational modifications, particularly phosphorylation, which can influence immune signaling and metabolic pathways[1]. Clinically, aberrant subcellular localization or function of SNAP23 has been linked to impaired glucose uptake in insulin resistance, and abnormalities in immune cell phagosome maturation and antigen processing[1][2][3].

Other names

Synaptosomal-associated protein 23SNAP-23SNAP23ASNAP23BHsT17016vesicle-membrane fusion protein SNAP-23synaptosomal-associated protein 23synaptosomal-associated protein, 23 kDasynaptosome associated protein 23kDa

Not applicable (no known approved drugs directly target SNAP23).