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Target intelligence / Profile preview
Synaptosomal-Associated Protein 25 (SNAP-25)
- Target
- SNAP-25
- Molecular classification
- t-SNARE protein
01
Overview
SNAP-25 (Synaptosomal-Associated Protein, 25kDa) is a t-SNARE protein and a key component of the SNARE complex, which mediates membrane fusion events critical for neurotransmitter release at synapses. It plays roles in synaptogenesis, neuronal plasticity, and postsynaptic receptor trafficking. Alterations or dysfunctions in SNAP‑25 are linked to several neurodevelopmental and neuropsychiatric disorders.
- Other names
- SNAP25
02
Mechanism of action
Modulation of SNARE complex formation and vesicle fusion
03
Biological functions
Vesicle fusion/exocytosisSynapse formationSynaptic plasticityNeurotransmitter release
04
Disease associations
Attention Deficit Hyperactivity Disorder (ADHD)SchizophreniaAlzheimer's diseaseBipolar disorderEpilepsyNeonatal development disordersLearning disabilities
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