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Target intelligence / Profile preview
Synaptosomal-associated protein 25kDa (SNAP25)
- Target
- SNAP25
- Molecular classification
- SNARE protein, Q-SNARE
01
Overview
SNAP-25 is a key component of the SNARE complex, essential for synaptic vesicle fusion and neurotransmitter release. It also plays a role in postsynaptic receptor trafficking and dendritic spine morphogenesis. Dysfunction or altered expression is linked to various neurodevelopmental and neuropsychiatric disorders. It is the target of botulinum neurotoxins, which cleave SNAP-25 and inhibit neurotransmitter release.
02
Mechanism of action
Botulinum neurotoxins cleave SNAP-25, inhibiting neurotransmitter release.
03
Biological functions
Neurotransmitter releaseSynaptic vesicle fusionVesicle dockingVesicle primingPostsynaptic receptor traffickingDendritic spine morphogenesisSynaptogenesisNeuronal plasticity
04
Disease associations
Attention deficit hyperactivity disorder (ADHD)SchizophreniaAlzheimer's diseaseBipolar disorderEpilepsyNeuroticismLearning disabilities
05
Safety considerations
Dysfunction or altered expression linked to several neurodevelopmental/neuropsychiatric disorders
06
Interacting drugs
Botulinum neurotoxins
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